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SUMMARY:Engineering riboswitches to enable rational control of transgene e
 xpression - Christopher Finch\, 1st yr grad
DTSTART:20150501T103000Z
DTEND:20150501T110000Z
UID:TALK58767@talks.cam.ac.uk
CONTACT:Helen Scott
DESCRIPTION:Microalgae are of particular interest for biotechnology becaus
 e they fix carbon from the atmosphere\, and can therefore sustainably prod
 uce fossil fuel substitutes\, as well as high-value compounds such as anti
 oxidants and pharmaceuticals. Genetic modification can increase the produc
 tivity of microalgae\, but currently only limited tools exist to control t
 he expression of added genes. Our lab has explored the use of endogenous g
 ene regulatory elements to modulate transgene expression in the model micr
 oalga Chlamydomonas reinhardtii. My research focuses on riboswitches\, mRN
 A motifs that regulate gene expression in response to binding a specific l
 igand. Here\, I show the versatility of native thiamine-responsive riboswi
 tches and describe my efforts to expand the regulatory properties of the T
 HI4 riboswitch.
LOCATION:Sainsbury Laboratory
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