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SUMMARY:Paramutation in tomato - Quentin Gouil\, 3rd yr grad
DTSTART:20150501T110000Z
DTEND:20150501T113000Z
UID:TALK58772@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:Paramutation is the copying of an allele's epigenetic state on
 to the other allele at the same locus. Examples of paramutation are rare i
 n plants\, and even rarer in animals. The historic sulfurea paramutation i
 n tomato (Hagemann 1958) leads to a yellowing of the leaves\, but the caus
 al locus is still unknown. I identify a candidate gene for sulfurea throug
 h mRNA-Seq and virus-induced gene silencing. The sulfurea phenotype was ge
 nerated through mutagenesis\, but paramutation can also occur between natu
 ral epialleles. I describe the first natural example of paramutation in to
 mato at a locus termed H06\, following hybrididation of the cultivated M82
  and its wild relative Solanum pennellii\, which highlights the importance
  of the RNA silencing machinery in this process. Finally\, genome-wide ana
 lysis of methylation in the introgression lines suggests that paramutation
  is not exceedingly rare\, and could play a role in the transgressive phen
 otypes of hybrids.
LOCATION:Sainsbury Laboratory
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