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SUMMARY:The Arabidopsis thaliana transcriptome is compressible - Surge Bis
 was\, 1st yr grad
DTSTART:20150611T120000Z
DTEND:20150611T123000Z
UID:TALK58780@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:Transcript levels are critical determinant of the proteome\, a
 nd hence cellular function. Because the transcriptome is an outcome of the
  interactions between genes and their products\, we reasoned it may be acc
 urately represented by a subset of transcript abundances. By analyzing tho
 usands of publicly available RNA-Seq datasets\, we show that the transcrip
 tome of Arabidopsis thaliana is highly compressible\, and can be faithfull
 y reconstructed using just the abundances of a small\, machine-learned sub
 set of 150 transcripts. These findings suggest natural improvements to bot
 h the time and cost of performing forward genetic screens and mapping eQTL
 s in naturally occurring populations. Understanding the rules by which the
  linear information encoded in the genome is read both in tissue and signa
 lling contexts is a central aim of biology. Our transcriptome compression 
 and prediction algorithms can facilitate dissection of this regulatory log
 ic.\n
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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