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SUMMARY:Metabolic cooperation in a synthetic yeast community - Kate Campbe
 ll (University of Cambridge)
DTSTART:20150514T121000Z
DTEND:20150514T130000Z
UID:TALK58810@talks.cam.ac.uk
CONTACT:Evros Loukaides
DESCRIPTION:Metabolic cooperation between two cell types is a common obser
 vation in many bacteria studies. However\, this same type of interaction i
 s less well observed in eukaryotes. Using the eukaryotic model organism\, 
 budding yeast\, we find that colonies have an abundance of metabolites in 
 the extra-­cellular space and in addition\, prefer to uptake these metabo
 lites over self­-synthesising them. We established a yeast colony which g
 radually develops metabolic deficiencies in amino acid and nucleobase meta
 bolism. Allowing its self­-establishment\, colony cells were able to ente
 r an efficient state of cooperation to overcome their metabolic deficienci
 es. We therefore conclude that the bottleneck of metabolic cooperation is 
 found in community structure. The established community reacted flexibly t
 o changes in nutrition\, and displayed non random distribution of cell typ
 es\, indicating a partitioning of metabolic roles between cells. On the si
 ngle cell level\, we find metabolic specialisation to be causally linked t
 o cell­-cell heterogeneity in response to heat and oxidative stress. Meta
 bolic cooperation is therefore effective in eukaryotes but is dependent on
  specific community structures to impose spatial and physiological diversi
 fication among single\, cooperating cells.
LOCATION:1 Newnham Terrace\, Darwin College
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