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SUMMARY:Cellular Systems Biology of Chromosome Dynamics - Dr Karen Lipkow 
 -  Barbraham Institute
DTSTART:20150513T130000Z
DTEND:20150513T140000Z
UID:TALK59266@talks.cam.ac.uk
CONTACT:David Greaves
DESCRIPTION:The questions of how genes are regulated remains fundamental e
 ven after many decades of intense study. Rather than just studying the lin
 ear\, one-dimensional sequence of DNA to inform us about regulatory mechan
 isms\, we can now investigate the complex 3-dimensional organisation of wh
 ole genomes. It has become clear that this organisation is non-random and 
 highly dynamic. To address new questions in genome architecture\, we are t
 aking a systems biology approach\, combining the bioinformatic determinati
 on of chromatin states with quantitative experiments and dynamic\, stochas
 tic models of whole genome organisation. These include polymer models of g
 enome structure and particle-based simulations of protein movements. Compa
 ring these results with our experimental data\, this has led us to underst
 and how biophysical properties of the chromatin fibre lead to significant 
 and biologically relevant self-organisation of the genome.
LOCATION:Lecture Theatre 1\, Computer Laboratory
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