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SUMMARY:Computational Neuroscience Journal Club - Guillaume Hennequin (Uni
 versity of Cambridge)
DTSTART:20150428T150000Z
DTEND:20150428T160000Z
UID:TALK59315@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:Guillaume Hennequin will cover: \n\n* Retrieval induces adapti
 ve forgetting of competing memories via cortical pattern suppression\n* M.
  Wimber\, A. Alink\, I. Charest\, N. Kriegeskorte & M. C. Anderson\n* Natu
 re Neuroscience\, 2015\n* http://www.nature.com/neuro/journal/v18/n4/full/
 nn.3973.html\n\nRemembering a past experience can\, surprisingly\, cause f
 orgetting. Forgetting arises when other competing traces interfere with re
 trieval and inhibitory control mechanisms are engaged to suppress the dist
 raction they cause. This form of forgetting is considered to be adaptive b
 ecause it reduces future interference. The effect of this proposed inhibit
 ion process on competing memories has\, however\, never been observed\, as
  behavioral methods are 'blind' to retrieval dynamics and neuroimaging met
 hods have not isolated retrieval of individual memories. We developed a ca
 nonical template tracking method to quantify the activation state of indiv
 idual target memories and competitors during retrieval. This method reveal
 ed that repeatedly retrieving target memories suppressed cortical patterns
  unique to competitors. Pattern suppression was related to engagement of p
 refrontal regions that have been implicated in resolving retrieval competi
 tion and\, critically\, predicted later forgetting. Thus\, our findings de
 monstrate a cortical pattern suppression mechanism through which rememberi
 ng adaptively shapes which aspects of our past remain accessible.
LOCATION:Cambridge University Engineering Department\, CBL\, BE-438 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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