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SUMMARY:LARMOR LECTURE - The statistical physics of stem cell biology: Dic
 ing with fate - Professor Benjamin D  Simons\, Herchel Smith Professor of 
 Physics\, Department of Physics
DTSTART:20151012T170000Z
DTEND:20151012T180000Z
UID:TALK59584@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:In adult\, tissues are maintained and repaired by stem cells\,
  which divide and differentiate to generate more specialized progeny. The 
 mechanisms that regulate the balance between stem cell proliferation and d
 ifferentiation promise fundamental insights into the origin and design of 
 multi-cellular organisms. However\, stem cells are difficult to distinguis
 h from their more differentiated offspring\, and resolving these mechanism
 s has proved challenging. Applied to genetic cell lineage tracing and in v
 ivo live-imaging studies\, we discuss how concepts from non-equilibrium st
 atistical physics and population dynamics are providing surprising new ins
 ights into common patterns of stem cell regulation in mammalian tissues. A
 s well as undermining some accepted paradigms in stem cell biology\, we sh
 ow how these methods provide a novel platform to explore factors leading t
 o dysregulation and the initiation of diseased states. 
LOCATION:Bristol-Myers-Squibb Lecture theatre\, Department of Chemistry
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