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SUMMARY:New proteomic insights into Malaria erythrocyte interactions - Pro
 fessor Duncan Cromarty
DTSTART:20150527T133000Z
DTEND:20150527T143000Z
UID:TALK59599@talks.cam.ac.uk
CONTACT:6290
DESCRIPTION:Malaria is a complex disease afflicting more than 250 million 
 people and almost 600 000 avoidable deaths per year. The Plasmodium falcip
 arum parasites responsible for the disease have the ability to develop res
 istance to antimalarial drugs through rapid mutations on the var2 gene res
 ulting in altered protein sequences. To date antimalarial vaccines are sho
 wing limited success due to protein alteration.\n\nThe recognition and att
 achment of the merozoite stage of the parasite to an uninfected erythrocyt
 e potentially also uses numerous alternative pathways to ensure rapid infe
 ction rates.\n\nDuring invasion a complex sequence of binding\, reorientat
 ion\, formation of a tight junction and internalisation accompanied by the
  release of surface proteins takes place. During the late trophozoite stag
 e the erythrocyte exposes several parasite proteins responsible for the ad
 hesion of infected cells in the microvasculature.\n\nModification of eryth
 rocyte surface proteins and drug treatments that alter the expressed paras
 ite proteins coupled with invasion assay data provide a platform to invest
 igate the potential target proteins using both classical and new proteomic
  techniques.\n\nSDS PAGE and nLC-MS/MS techniques have identified two poss
 ibly overlooked proteins affecting invasion success and a truncated form o
 f an adhesion protein has been identified.\nSome potential shortcomings of
  the approach will be highlighted\n
LOCATION:Department of Biochemistry - Sanger Building\, Seminar Room
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