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SUMMARY:Rogue states: altered dimensionality of neural circuit activity in
  Fragile-X mice - Cian O'Donnell\, Computational Neurobiology Lab\, Salk I
 nstitute\, La Jolla
DTSTART:20150526T100000Z
DTEND:20150526T110000Z
UID:TALK59635@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:Brain disorders such as autism and schizophrenia have been hyp
 othesized to arise from an imbalance in excitation/inhibition in neural ci
 rcuits. Why or how such an imbalance would be detrimental for neural codin
 g remains unclear. We approached the problem by analysing two-photon in vi
 vo neural population recordings from the cortex of both wild-type and Frag
 ile-X Syndrome model mice at different stages of development. We developed
  a new statistical model for the probability distribution of all 2^N^ poss
 ible neural population activity patterns that required only N^2^ parameter
 s\, where N is the number of neurons. Using this model we  found that the 
 dimensionality of population activity was lower in Fragile-X than wild-typ
 e mice at adolescence\, but surprisingly switched in adulthood so that Fra
 gile-X dimensionality was higher than wild-type. Finally we used a computa
 tional model of layer 2/3 somatosensory cortex to show which neural circui
 t components can give rise to these alterations in dimensionality. Our fin
 dings show how small changes in neural circuit parameters can have dramati
 c consequences for information processing.\n
LOCATION:Cambridge University Engineering Department\, CBL\, BE-438 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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