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SUMMARY:Mapping shared markers for a childhood liver disease across a Poly
 nesian population - Sophia Cameron-Christie\, University of Otago\, New Ze
 aland
DTSTART:20150615T153000Z
DTEND:20150615T163000Z
UID:TALK59726@talks.cam.ac.uk
CONTACT:Aurélien Mounier
DESCRIPTION:Populations that are small and under-studied present a particu
 lar problem for studying the genetics of multifactorial human traits\, whe
 re normal variation and allele frequencies are uncharacterized. We present
  an investigation of biliary atresia (BA)\, a usually sporadic malformatio
 n of the biliary tree. Worldwide\, BA leads to half of all paediatric live
 r transplants\, and is always fatal without major surgical intervention. T
 he causes of BA remain unknown\; autoimmune processes and genetic backgrou
 nd may both play a part. In New Zealand Māori and Polynesian populations 
 the incidence is elevated three-fold compared to Europeans. We have identi
 fied a large Māori family (iwi) exhibiting an extremely elevated incidenc
 e of BA (1:100–300 live births). To circumvent some of the problems in s
 tudying complex traits in Maori we have adopted a non-parametric\, family-
 based approach that maps long\, Identical-By-State (IBS) segments across a
 ffected individuals. This allows investigation without reliance on pre-exi
 sting assumptions about allele frequencies\, a definitive inheritance mode
 l or exclusion of unidentified phenocopies
LOCATION:BioAnth Lecture Theatre (Room 41)\, Division of Biological Anthro
 pology\, Pembroke Street\, Cambridge\, CB2 3QG
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