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SUMMARY:The origin of early lineages in the mammlian embryo - Dr. Berenika
  Plusa
DTSTART:20150622T090000Z
DTEND:20150622T100000Z
UID:TALK59864@talks.cam.ac.uk
CONTACT:38171
DESCRIPTION:The development of an entire organism from a single fertilized
  egg is arguably one of the most fascinating processes in biology. In euth
 erian mammals the whole process starts before embryo implants into the ute
 rus. From around the 8-cell stage\, originally identical embryonic cells -
  blastomeres gradually become committed to one of the first three cell lin
 eages: the trophectoderm (TE)\, the primitive endoderm (PrE)\, which both 
 contribute to the placenta\, and the pluripotent epiblast (EPI)\, which gi
 ves rise to the foetus and later to the whole adult organism. At the blast
 ocyst stage\, TE consists of a single layer of cells (“epithelium”) en
 closing a fluid-filled cavity and an adjacent inner cell mass (ICM). By th
 e late blastocyst stage\, the PrE appears as a noticeable layer of cells o
 n the surface of the ICM lining the cavity\, with deeper cells constitutin
 g the EPI. Although the emergence of all three embryonic lineages is a com
 mon phenomenon among mammals\, some apparent differences can be observed d
 uring lineage specification between different mammalian species. It is the
 refore paramount to gain the insight into early differentiative events\, t
 o pinpoint the processes and mechanisms that are universal for various mam
 mals.
LOCATION:Pharmacology Lecture Theatre\, Department of Pharmacology\, Tenni
 s Court Road
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