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SUMMARY:Computational Neuroscience Journal Club - Daniel McNamee
DTSTART:20150623T150000Z
DTEND:20150623T160000Z
UID:TALK59919@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:Daniel McNamee will cover\n\n* Orbitofrontal Cortex Encodes Me
 mories within Value-Based Schemas and Represents Contexts That Guide Memor
 y Retrieval\n* A Farovik\, R J Place\, S McKenzie\, B Porter\, C E Munro\,
  and H Eichenbaum\n* J Neurosci (2015)\n* http://www.jneurosci.org/content
 /35/21/8333.short\n\nThere are a substantial number of studies showing tha
 t the orbitofrontal cortex links events to reward values\, whereas the hip
 pocampus links events to the context in which they occur. Here we asked ho
 w the orbitofrontal cortex contributes to memory where context determines 
 the reward values associated with events. After rats learned object–rewa
 rd associations that differed depending on the spatial context in which th
 e objects were presented\, neuronal ensembles in orbitofrontal cortex repr
 esented distinct value-based schemas\, each composed of a systematic organ
 ization of the representations of objects in the contexts and positions wh
 ere they were associated with reward or nonreward. Orbitofrontal ensembles
  also represent the different spatial contexts that define the mappings of
  stimuli to actions that lead to reward or nonreward. These findings\, com
 bined with observations on complementary memory representation within the 
 hippocampus\, suggest mechanisms through which prefrontal cortex and the h
 ippocampus interact in support of context-guided memory.\n
LOCATION:Cambridge University Engineering Department\, CBL\, BE-438 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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