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SUMMARY: Episodic Memory and Spatial Navigation in the Medial Temporal Lob
 e - Dr David E Huber - Department of Psychological and Brain Sciences Univ
 ersity of Massachusetts\, Amherst
DTSTART:20150630T120000Z
DTEND:20150630T130000Z
UID:TALK59965@talks.cam.ac.uk
CONTACT:Lorraine Coulson
DESCRIPTION:Hippocampal place cells and entorhinal grid cells are abundant
 \, suggesting that the medial temporal lobe (MTL) primarily supports spati
 al navigation. At the same time\, neuropsychological studies find that the
  MTL supports the formation of episodic memories. We explain this seeming 
 contradiction with a hierarchical memory model in which episodic memories 
 are points in a high dimensional space. Because the X/Y dimensions used to
  analyze place and grid cells are part of this representation\, different 
 levels of the hierarchy give the appearance of place and grid cells when o
 nly analyzed in terms of the X/Y plane. We propose that X/Y position infor
 mation is provided by border cells\, which is combined with the true attri
 butes of grid cells (e.g.\, something other than X/Y\, such as temperature
 \, surface texture\, time of day\, etc.) to produce cognitive maps and ult
 imately multidimensional episodic memories in the hippocampus. Place cell 
 responses are retrieved memory responses that occur when the animal is in 
 a position sufficiently close to the location of a prior experience. Memor
 y consolidation separates memories in the multidimensional space\, produci
 ng a hexagonal array of place cells. The response of a cell representing a
  non-spatial attribute common to the entire set of memories is hexagonal i
 n the X/Y plane owing to excitatory feedback from each place cell. Thus\, 
 rather building place cells out of grid cells\, as proposed by other model
 s\, our account builds grid cells out of place cells. Furthermore\, our ac
 count proposes that place cells are episodic memories and grid cells are n
 on-spatial.
LOCATION:Kenneth Craik Room\, Craik Marshall Building\, Downing Site\, Cam
 bridge
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