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SUMMARY:Start-up designs for response-adpative randomization procedures - 
 Haines\, L (University of Cape Town)
DTSTART:20150706T110000Z
DTEND:20150706T113000Z
UID:TALK60043@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:Response-adaptive randomization procedures are appropriate for
  clinical trials in which two or more treatments are to be compared\, pati
 ents arrive sequentially and the response of each patient is recorded befo
 re the next patient arrives. For those procedures which involve sequential
  estimation of model parameters\, start-up designs are commonly used in or
 der to provide initial estimates of the parameters. In this talk a suite o
 f such start-up designs for two treatments and binary patient responses ar
 e considered and compared in terms of the numbers of patients required in 
 order to give meaningful parameters estimates\, the number of patients all
 ocated to the better treatment and the bias in the parameter estimates. It
  is shown that permuted block designs with blocks of size 4 are to be pref
 erred over a wide range of parameter values. Results from a simulation stu
 dy involving complete trials will also be reported.\n
LOCATION:Seminar Room 1\, Newton Institute
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