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SUMMARY:Designing an adaptive trial with treatment selection and a surviva
 l endpoint - Jennison\, C (University of Bath)
DTSTART:20150706T090000Z
DTEND:20150706T094500Z
UID:TALK60045@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:We consider a clinical trial in which two versions of a new tr
 eatment are compared against control with the primary endpoint of overall 
 survival. At an interim analysis\, mid-way through the trial\, one of the 
 two treatments is selected\, based on the short term response of progressi
 on-free survival. For such an adaptive design the familywise type I error 
 rate can be protected by use of a closed testing procedure to deal with th
 e two null hypotheses and combination tests to combine data from before an
 d after the interim analysis. However\, with the primary endpoint of overa
 ll survival\, there is still a danger of inflating the type I error rate: 
 we present a way of applying the combination test that solves this problem
  simply and effectively. With the methodology in place\, we then assess th
 e potential benefits of treatment selection in this adaptive trial design.
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LOCATION:Seminar Room 1\, Newton Institute
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