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SUMMARY:Some critical issues in adaptive experimental designs for treatmen
 t comparisons - Giovagnoli\, A (University of Bologna)
DTSTART:20150706T131500Z
DTEND:20150706T140000Z
UID:TALK60046@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:The study of adaptive designs has received impetus over the pa
 st 20 years\, mainly because of its potential in applications to clinical 
 trials\, and a large number of these designs is now available in the stati
 stical and biomedical literature\, starting from simple ones like Efrons B
 iased Coin Design and Zelens Play-the-Winner\, to the more  \nsophisticate
 d  ones: D_A-optimum Biased Coin designs\, Doubly-Adaptive designs\,  ERAD
 E\,  Randomly Reinforced Urns\, Reinforced Doubly-Adaptive  Biased Coins\,
  etc.\, not forgetting covariates (Covariate-Adjusted  Response-Adaptive\,
  Covariate-Adaptive Biased Coin\, Covariate-adjusted Doubly-adaptive Biase
 d Coin designs\, etc.).\n\nA complicating factor is that nowadays adaptive
  experiments are in general multipurpose:  they try to simultaneously achi
 eve inferential efficiency\, bias avoidance\, and utilitarian or ethical g
 ains. Another is the very nature of an adaptive design\, which is a random
  \nexperiment that may or may not converge to a fixed treatment allocation
 .  \n\nThis talk does not intend to be a survey of the existing literature
 \, rather it is an effort to highlight potentially critical points: infere
 nce after an adaptive experiment\, combined versus constrained optimizatio
 n\, speed of convergence to a desired target\, possible  \nmisuse of simul
 ations.  Each of these points will be discussed with reference to one or m
 ore specific adaptive designs.\n
LOCATION:Seminar Room 1\, Newton Institute
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