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SUMMARY:Adaptive dose-finding with power control - Miller\, F (Stockholm U
 niversity)
DTSTART:20150706T101500Z
DTEND:20150706T110000Z
UID:TALK60048@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:A main objective in dose-finding trials besides the characteri
 sation of dose-response relationship is often to prove that the drug has e
 ffect. The sample size calculation prior to the trial aims to control the 
 power for this effect proof. In most cases however\, there is great uncert
 ainty concerning the anticipated effect of the drug during planning. Sampl
 e size re-estimation based on an unblinded interim effect estimate has bee
 n used in this situation. In practice\, this re-estimation can have drawba
 cks as sample size becomes variable which makes planning and funding compl
 icated. Further it introduces the risk \nthat people start to speculate ab
 out the effect once the re-estimated sample size is communicated. In this 
 talk\, we will investigate a design which avoids this problem but controls
  the power for the effect proof in an adaptive way. We discuss methods for
  proper statistical inference for the described design.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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