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SUMMARY:Randomization for small clinical trials - Rosenberger\, B (George 
 Mason University)
DTSTART:20150710T100000Z
DTEND:20150710T104500Z
UID:TALK60103@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:Rare disease clinical trials present unique problems for the s
 tatistician designing the study.  First\, the trial may be small to reflec
 t the uniquely small population of diseased in the population.  Hence\, th
 e usual large sample beneficial properties of randomization (balancing on 
 unknown covariates\, distribution of standard tests\, converging to a targ
 et allocation) may not apply.  We describe the impact of such trials on co
 nsideration of randomization procedures\, and discuss randomization as a b
 asis for inference.  We conclude that\, in small trials\, the randomizatio
 n procedure chosen does matter\, and randomization tests should be used as
  a matter of course due to its property of preserving the type I error rat
 e under time trends.\n
LOCATION:Seminar Room 1\, Newton Institute
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