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SUMMARY:Assessment of randomization procedures based on single sequences u
 nder selection bias - Hilgers\, R-D (RWTH Aachen University)
DTSTART:20150710T104500Z
DTEND:20150710T113000Z
UID:TALK60105@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:Randomization is a key feature of randomized clinical trials a
 iming to protect against various types of bias. Different randomization pr
 ocedures were introduced in the past decades and their analytical properti
 es have been studied by various authors. Among others\, balancing behaviou
 r\, protection against selection and chronological bias etc have been inve
 stigated.  However\, in summary no procedure performs best on all criteria
 . On the other hand\, in the design phase of a clinical trial the scientis
 t has to select a particular\nrandomization procedure to be used in the al
 location process which takes into account the research conditions of the t
 rial. Up to now\, less support is available to guide the scientist hereby\
 , e.g. to weigh up the properties with respect to practical needs of the r
 esearch question to be answered by the clinical trial. We propose a method
  to assess the impact of chronological and selection bias in a parallel gr
 oup randomized clinical trial with continuous normal outcome on the probab
 ility of type one error to derive scientific arguments for selection of an
  appropriate randomization procedure. \n\nThis is joint work with Simon La
 nger.\n
LOCATION:Seminar Room 1\, Newton Institute
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