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SUMMARY:Efficient study designs - Julious\, S (University of Sheffield)
DTSTART:20150710T080000Z
DTEND:20150710T084500Z
UID:TALK60106@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:In the current economic climate there is a tightening of resea
 rch income \nwhile the demand to answer important clinical questions it co
 uld be \nargued is the same or is even increasing.  Efficient study design
 s \nenable the questions to be answered while making optimal use of finite
  \nresource.\n\nAn efficient design is defined as "statistically robust" d
 esigns that \nfacilitate quicker and/or lower cost decisions when compared
  to \nconventional trial design.  An efficient design is an umbrella term 
 \nwhich encompasses aspects such adaptive designs and trials where routine
  \nhealth service data are used for the primary outcomes as well as \n"sma
 rter" ways of doing trials.  By being efficient in the study design \nreso
 urces and time can be saved in the assessment of new health technologies.\
 n\nThrough a series case studies the benefits of efficient study designs w
 ill be highlighted.  For example: The PLEASANT trial used routinely collec
 ted data for data collection and as a result was approximately 1 million c
 heaper\; retrospective analysis of RATPAC as a group sequential showed tha
 t if the trial had been adaptive it would have required a third of the pat
 ients and saved 250\,000. An audit of public funded trials suggested that 
 if futility were undertaken then 20% of trials would stop early and the pr
 oportion of successfully recruiting trials would increase from 45% to 64%.
   As well as highlighting the benefits the presentation will also discuss 
 some of the challenges.\n
LOCATION:Seminar Room 1\, Newton Institute
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