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SUMMARY:Early adversity\, stress response\, hippocampal development and ri
 sks of psychiatric and neurological diseases - Dr Veronique Bohbot - Facul
 ty of Medicine\, McGill University\, Quebec\, Canada
DTSTART:20150907T120000Z
DTEND:20150907T130000Z
UID:TALK60208@talks.cam.ac.uk
CONTACT:Lorraine Coulson
DESCRIPTION:Abstract: \nA larger hippocampus has been associated with heal
 thy cognition in normal aging and with a reduced risk of numerous neurolog
 ical and psychiatric disorders such as Alzheimer’s disease\, Schizophren
 ia\, Post-Traumatic Stress disorder and Depression.\n \nThe hippocampus is
  implicated in only one of two navigation strategies utilized when finding
  one’s way in the environment. The spatial strategy involves remembering
  the relationship between environmental landmarks to form a cognitive map\
 , whereas the response strategy relies on making a series of stimulus-resp
 onse associations (e.g. right and left turns) from a given position. Parti
 cipants who spontaneously use the spatial strategy show increased fMRI act
 ivity and grey matter in the hippocampus relative to those spontaneously u
 sing the response strategy. Response learners\, on the other hand\, show i
 ncreases in activity and grey matter in the caudate nucleus as well as atr
 ophy in the hippocampus relative to spatial learners. Recent results from 
 our laboratory show that spatial and response learners differ in terms of 
 cortisol levels in adulthood\, childhood and infancy. They differ in terms
  of their cortisol response to a psychological and physical stressor and t
 heir brains develop in different ways throughout childhood. Factors modula
 ting spatial and response strategies include genes\, prenatal stress\, rew
 ard\, and experience.\n 	\n
LOCATION:Kenneth Craik Room\, Craik Marshall Building\, Downing Site\, Cam
 bridge
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