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SUMMARY:Idas and Lynkeas control Radial glial cells commitment to ependyma
 l lineage  - Stavros Taraviras Ph.D\, Department of Physiology\, Medical S
 chool\, University of Patras 
DTSTART:20150720T110000Z
DTEND:20150720T120000Z
UID:TALK60215@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:A small subpopulation of Radial glial cells\, contributes to t
 he generation of adult neural stem cells and multiciliated ependymal cells
 \, which reside in the subependymal zone at lateral walls of the adult cor
 tex. We provide evidence that Idas and Lynkeas\, two novel proteins sharin
 g homology with Geminin\, are the earliest known marker of radial glial ce
 lls committed to the ependymal cell lineage in the developing mouse brain.
  RGs upon Idas or Lynkeas overexpression loss their neural stem cells char
 acteristics and prematurely differentiated into multiciliated ependymal ce
 lls\, while inactivation experiments resulted in blockage of multiciliated
  ependymal cells generation. We have also shown that Idas and Lynkeas act 
 upstream of known transcription factors essential for the commitment and d
 ifferentiation of RGs towards ependymal cells\, while they are negatively 
 regulated by Notch pathway. Our results suggest that Idas and Lynkeas are 
 key players for radial glial cells fate commitment and differentiation to 
 multiciliated ependymal cells. 
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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