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SUMMARY:Intensified-Process Integration at All Scales  – flow reactor ne
 tworks and end-to-end intensified chemical plants - Prof. Volker Hessel\, 
 Eindhoven University of Technology
DTSTART:20160218T143000Z
DTEND:20160218T153000Z
UID:TALK60292@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:Flow Chemistry provides chemical intensification. Novel Proces
 s Windows achieve the latter through exploration of unusual and typically 
 harsh process conditions with much enhanced activation and also chance for
  different selectivity pattern. A survey based on several own-developed fl
 ow chemistries will underpin the boost of reactivity via high-T\, high-p\,
  high-c (solvent-free\; alternative solvent) concepts. Moreover\, photo-ca
 talytic micro-flow synthesis is on the way of giving a large push to that 
 kind of processing and some own examples will be referenced. Yet\, the big
  chance is to make the chemistry entirely different. Two major ways will b
 e reported: (i) flow cascades which shrink multi-step syntheses together\;
  (i) direct green pathways from inactive\, non-functionalized resource mat
 erials (C-H activation\, N fixation\, CO2 utilization).\n\nThis will be ma
 jorly exemplified at two examples. First\, an LCA / green metrics study gi
 ves insight into the greenness of a micro-flow multi-step synthesis of ruf
 inamide\, an antiepileptic drug to treat the Lennox–Gastaut syndrome. Af
 ter chemical intensification concepts were settled\, those and hypothetica
 l opportunities for intensification were tested on their impact on environ
 mental friendliness. This involves opportunity-impact analysis for the ful
 l retrosynthetic process chain down to nitrobenzene as bulk chemical. The 
 ecological backpack of three different retrosynthetic process chains is de
 monstrated. For the first time\, three different microreactor networks are
  compared for their LCA profile. This will give answer to the question if 
 such networks are “just” multiple retrofit insertions or provide a pat
 h to end-to-end process design.\n\nThe second example is even more radical
  towards end-to-end process design. The motto ‘Chemergy’ stands for th
 e unanimously forecasted “Electrification of the Chemi-cal Industry” t
 hrough sustainable energy sources. Several European roadmaps pro-claim tha
 t change\, e.g. Dechema discussion paper (of same name)\, ISPT Topsector E
 nergie: ‘Power2Products’\, Enquete Commission “Future of the Chemica
 l Industry in NRW”\, and TKI’s 2015 Technology Roadmap “Making Susta
 inable Chemical Products”. This reintro¬duction of “electrons in the 
 chemical industry” is seen as contri-bution towards a circular economy. 
 Along these lines\, the plasma-catalytic processing was applied for nitrog
 en fixation using air (N2) to manufacture NO/NO2 which finally is converte
 d to nitric acid and fertilizers. The business model hereabout is tightly 
 con-nected to green renewable energy sources and mobile\, compact containe
 r production platforms. Both together enable to utilize the power of wind/
 solar/biomass sources at the distributed sites of the electricity for manu
 facturing a chemical product (nitric acid). That might be directly further
  upgraded to a fertilizer (or urea etc.) to achieve a higher value-added p
 roduct. Proof of principle\, cost & LCA studies will be shown.\n
LOCATION:Pfizer  Lecture Theatre\,  Department of Chemistry
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