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SUMMARY:Into the void: bridging the gap between risk genes and psychiatric
  phenotypes. - Dr Elizabeth Tunbridge\, Department of Psychiatry\, Univers
 ity of Oxford
DTSTART:20151008T130000Z
DTEND:20151008T140000Z
UID:TALK60344@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Recent genome-wide association studies have identified risk fa
 ctors that are robustly associated with psychiatric disorders. However\, m
 oving from the knowledge that ‘Variant X is associated with Disorder Y
 ’\, to an understanding of the underlying causative mechanisms\, and\, u
 ltimately\, to novel\, rational treatments\, is a mammoth task. I will exp
 lore potential strategies to address this challenge. As well as drawing fr
 om findings from the wider field\, I will illustrate this argument using e
 xamples from my own research. First\, I will show how translating\, and ba
 ck-translating\, between animal models and studies in human volunteers\, c
 an provide understanding of the mechanisms by which genes of interest can 
 be linked with whole brain function\, as well as generating novel hypothes
 es. I will then outline how human neuroimaging can provide clues to the ne
 urobiological effects of genes whose function is unknown in the brain. 
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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