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SUMMARY:Intra-tumour heterogeneity and genomic rearrangements in solid can
 cers. - Dr Roland Schwarz\, European Bioinformatics Institute\, Wellcome T
 rust Genome Campus\, Hinxton 
DTSTART:20151015T130000Z
DTEND:20151015T140000Z
UID:TALK60345@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Accurate reconstruction of the evolutionary history of cancer 
 in the\npatient and quantification of intra-tumour heterogeneity (ITH) are
  current\nchallenges in cancer genomics. Genomic rearrangements are thereb
 y \nof particular importance\, but notoriously difficult to deal with comp
 utationally.\nThe accuracy of tree inference from genomic rearrangements f
 urther depends \non the quality of the phasing of copy-numbers: the assign
 ment of major and \nminor copy-numbers to the two physical parental allele
 s. So far\, phasing has \nbeen done using evolutionary criteria alone\, a 
 heuristic and computationally \nexpensive procedure which impedes probe-le
 vel resolution tree reconstruction.\n\nI will give an overview of the chal
 lenges and current state of research in \nreconstructing cancer trees from
  copy-number data. Results from our \nclinical studies demonstrate how ITH
  is associated with chemotherapy \nresistance in the clinic. I will furthe
 r illustrate the importance of haplotype-\nspecific copy-number assignment
  and show how the common genetic \nbackground between multiple samples fro
 m the same patient can be used\nto accurately phase copy-number data. This
  is a crucial step towards probe-level\nresolution tree inference on genom
 ic rearrangement events in cancer\nand exact quantification of genetic het
 erogeneity for routine\napplications in translational cancer research.
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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