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SUMMARY:Genomics approaches for the investigation of  gene regulation. - D
 r Jim Hughes\, Hughes Genome Biology Group\, Oxford 
DTSTART:20151119T140000Z
DTEND:20151119T150000Z
UID:TALK60350@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:"A main research interest of the group is to study the process
 es that determine whether RNA is or is not produced from a genomic locus a
 s cells develop into red blood cells (erythropoiesis) and which factors de
 termine the rate at which it is produced. We employ most of the current ge
 nome-wide methods to determine which parts of the genome are being transcr
 ibed into RNA and to correlate this activity (transcription) with molecula
 r changes at the linked regulatory elements and in the 3D structure of the
  local environments. Although we use many existing methodologies the group
  also develops novel assays where needed to fill many of the current defic
 iencies in our ability to assess genome behaviour.  One of the most diffic
 ult problems when trying to understand gene regulation on the scale of gen
 ome or at individual genes is to determine which regions of the genome con
 trol the expression patterns and levels of any particular gene.  To addres
 s this problem we developed the Capture-C 3C technologies\, which in combi
 nation with our combined genomics data\, allows us to link genes and regul
 atory elements en masse in the erythroid system."
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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