BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Deciphering signaling specificity in development\, one phosphate a
 t a time - Professor Phillipe Soriano\, Mount Sinai Hospital\, NY
DTSTART:20150915T110000Z
DTEND:20150915T120000Z
UID:TALK60427@talks.cam.ac.uk
CONTACT:Sarah Harrison
DESCRIPTION:_Receptor tyrosine kinases (RTKs) signal through shared intrac
 ellular pathways yet mediate distinct outcomes across many cell types. To 
 investigate the mechanisms underlying RTK specificity\, we have generated 
 allelic series of mutations in PDGF and FGF receptor genes that prevent en
 gagement of individual signaling pathways. These studies have provided ins
 ight into the mechanisms underlying signaling specificity\, and identified
  both effector mediated outputs as well as responses originating from inte
 gration of multiple pathways. We have further identified distinct transcri
 ptional programs\, intracellular pathway usage\, and cellular outcomes in 
 response to these growth factors using RNA-Seq\, in the context of craniof
 acial development. Collectively\, our results delineate distinct responses
  to PDGF and FGF signaling in development. More generally\, these studies 
 provide insight into the mechanisms encoding transcriptional specificity i
 n response to RTK signaling._
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
END:VEVENT
END:VCALENDAR