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SUMMARY:Gene and Genome Regulation in Early Fruit Fly Neurogenesis. - Dr. 
 Robert Zinzen\, Max-Delbruck-Center Berlin
DTSTART:20160303T140000Z
DTEND:20160303T150000Z
UID:TALK60489@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:From fertilized egg to complex adult lies a world of regulatio
 n\, specialization and differentiation. The main aim our lab is to address
  the question  ‘How do cells acquire and maintain their identities?’. 
 More specifically\, we are interested in (i.) the gene regulatory mechanis
 ms that specify the neurogenic ectoderm (NE) in the early embryo\, (ii.) h
 ow the NE then subdivides into specific domains that will give rise to dis
 crete parts of the embryonic nervous system (NS)\, and (iii.) how distinct
  sets of neuroblasts (NBs) delaminating from these domains acquire and mai
 ntain their identities and developmental trajectories. To elucidate the re
 gulatory networks underlying neurogenesis\, we combine developmental genet
 ics and genomics approaches in the Drosophila model system.\n\nThree consi
 derations are especially important to us: Regulatory data should (a) encom
 pass and resolve the developmental dynamics\, (b) be derived from developi
 ng embryos where possible\, as cultured models cannot fully recapitulate t
 he complex interactions present in the embryo over the course of developme
 nt\, and (c) the regulatory data should be acquired with tissue specificit
 y. This is especially challenging when the tissue-specific signatures of u
 biquitous features (e.g. chromatin state) are to be assessed.\n\nWe aim to
  establish a dynamic regulatory model of early neurogenesis through the in
 tegration of data at complementary regulatory levels (e.g. transcriptomics
 \, epigenomics\, TF binding) to better understand the developmental roles 
 of individual network components from tissue specification to the start of
  differentiation. The seminar will include examples of how we probe early 
 neurogenesis at different regulatory levels\, including a new approach we 
 are developing to biochemically screen for new components of the regulator
 y networks driving neurogenesis.
LOCATION:Part II Room\, Department of Genetics
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