BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Theoretical model for persistent and oscillatory cell motility - G
 ov\, N (Weizmann Institute of Science)
DTSTART:20150826T100000Z
DTEND:20150826T113000Z
UID:TALK60527@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:Cell movement has essential functions in development\, immunit
 y and cancer.  Various cell migration patterns have been reported\, such a
 s Brownian motion\, intermittent and persistent random-walks\, but no gene
 ral rule has emerged so far. Here\, we show on the basis of experimental d
 ata in vitro and in vivo that cell persistence\, which quantifies the stra
 ightness of trajectories\, is robustly coupled to cell migration speed. We
  suggest that this universal coupling constitutes a generic law of cell mi
 gration\, which originates in the advection of polarity cues by an actin c
 ytoskeleton undergoing flows at the cellular scale. \nOur analysis relies 
 on a theoretical model that we validate by measuring the persistence of ce
 lls upon modulation of actin flow speeds. Beyond the quantitative predicti
 on of the coupling\, the model yields a generic phase diagram of cellular 
 trajectories\, which recapitulates the full range of observed migration pa
 tterns.  Recent extensions of this model describe the oscillatory motion o
 f dendritic cells\, which compare very well with experiments.\n\nActin Flo
 ws Mediate a Universal Coupling between Cell Speed and Cell Persistence Ma
 iuri P\, Rupprecht JF\, Wieser S\, Ruprecht V\, Benichou O\, Carpi N\, Cop
 pey M\, De Beco S\, Gov N\, Heisenberg CP\, Crespo CL\, Lautenschlaeger F\
 , Le Berre M\, Lennon-Dumenil AM\, Raab M\, Thiam HR\, Piel M\, Sixt M\, V
 oituriez R\, Cell 161 \, 374-386 (2015)\n\n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
END:VEVENT
END:VCALENDAR