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SUMMARY:How to Understand Molecular Transport through Channels: The Role o
 f Interactions - Prof. Anatoly B. Kolomeisky\, Center for Theoretical Biol
 ogical Physics\, Rice University\, Department of Chemistry\,  Houston
DTSTART:20151030T140000Z
DTEND:20151030T150000Z
UID:TALK60611@talks.cam.ac.uk
CONTACT:Dr. Hernandez-Ainsa
DESCRIPTION:The motion of molecules across channels and pores is criticall
 y important for understanding mechanisms of many biological\, chemical\, p
 hysical and industrial processes. Here we investigate the role of differen
 t types of interactions in the channel-facilitated molecular transport by 
 analyzing exactly solvable discrete-state stochastic models. According to 
 this approach\, the channel transport is a non-equilibrium process that ca
 n be viewed as a set of coupled quasi-chemical transitions between discret
 e spatially separated states. It allows us to obtain a full dynamic descri
 ption of the translocation via the pore\, clarifying many aspects of these
  complex processes. We show that the strength and the spatial distribution
  of the molecule/channel interactions can strongly modify the particle flu
 xes through the system. Our analysis indicates that the most optimal trans
 port is achieved when the binding sites are near the entrance or near the 
 exit of the pore\, depending on the sign of interaction potentials. These 
 observations agree with single-molecule experiments on translocation of po
 lypeptides through biological channels. We also hypothesize that intermole
 cular interactions during the channel transport might also significantly i
 nfluence the translocation dynamics. Our explicit calculations show that t
 he increase in the flux can be observed for some optimal interaction stren
 gths.  The relevance of these results for biological systems is discussed.
  The physical-chemical mechanisms of these phenomena are discussed from th
 e microscopic point of view.\n
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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