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SUMMARY:Substituted Nucleotides: versatile building blocks in DNA bio-nano
 technology - Prof. Eugen Stulz\, School of Chemistry and Institute for Lif
 e Sciences\, University of Southampton
DTSTART:20151016T130000Z
DTEND:20151016T140000Z
UID:TALK60612@talks.cam.ac.uk
CONTACT:Dr. Hernandez-Ainsa
DESCRIPTION:DNA has become very attractive as scaffold for functional mole
 cules on the nanometre scale[1]. The sequence specific insertion of modifi
 ed nucleotides using automated DNA synthesis allows for the creation of ne
 w designer molecules with a wide range of potential applications. We have 
 established a general synthetic route to porphyrin-nucleosides and their s
 ubsequent site specific incorporation into oligonucleotides to create mult
 iporphyrin arrays. Up to eleven consecutive porphyrins could be incorporat
 ed into DNA giving access to a multiporphyrin array of approximately 10 nm
  in length\, which corresponds to the highest amount of DNA modification w
 ith a large hydrophobic metal complex to date [2]. The spectroscopic data 
 and structure calculations indicate the formation of a stable helical arra
 y in the single strand porphyrin-DNA. The π-stack of the porphyrins leads
  to strong electronic interaction between the chromophores. A zipper array
  with induced stability and energy transfer properties has recently been r
 ealised\, providing access to the first reversible photonic wire based on 
 a DNA scaffold [3].\nHere our latest results in terms of novel modified DN
 A structures\, including their characterization using CD and EPR spectrosc
 opy\, will be presented. Applications of modified DNA will be described\, 
 such as genosensors [4]\, switches [5] and DNA origami nanopores [6]\; ong
 oing projects in G-quadruplex stabilisation and DNA origami enzyme assembl
 ies will be shown as well.\n \n\nReferences\n\n1-Bandy\, T. J.\, Brewer\, 
 A.\, Burns\, J. R.\, Marth\, G.\, Nguyen\, T.\, Stulz\, E.\, Chem. Soc. Re
 v.\, 2011\, 40\, 138-148.\n\n2-Fendt\, L. A.\, Bouamaied\, I.\, Thöni\, S
 .\,Amiot\, N.\, Stulz\, E.\, J. Am. Chem. Soc.\, 2007\, 129\, 15319-15329.
 \n\n3-Nguyen\, T.\, Brewer\, A.\, Stulz\, E.\, Angew. Chem. Int. Ed.\, 200
 9\, 48\, 1974-1977.\n\n4-Grabowska\, I.\; Singleton\, D. G.\; Stachyra\, A
 .\; Gora-Sochacka\, A.\; Sirko\, A.\; Zagorski-Ostoja\, W.\; Radecka\, H.\
 ; Stulz\, E.\; Radecki\, J.\, Chem. Commun. 2014\, 50 (32)\, 4196-4199.\n\
 n5-Burns\, J. R.\, Preus\, S.\, Singleton\, D. G.\, Stulz\, E.\, Chem. Com
 mun.\, 2012\, 48\, 11088-11090.\n\n6- a) Burns\, J. R.\, Stulz\, E.\, Howo
 rka\, S.\, Nano Lett.\, 2013\, 13\, 2351-2356\; b) Burns\, J. R.\, Gopfric
 h\, K.\, Wood\, J. W.\, Thacker\, V. V.\, Stulz\, E.\, Keyser\, U. F.\, Ho
 worka\, S.\, Angew. Chem.-Int. Edit.\, 2013\, 52\, 12069-12072.\n
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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