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SUMMARY:Metabolite damage and its repair or pre-emption - Prof. Andrew Han
 son\, Horticultural sciences department (University of Florida)
DTSTART:20151005T130000Z
DTEND:20151005T143000Z
UID:TALK60683@talks.cam.ac.uk
CONTACT:42538
DESCRIPTION:It is increasingly evident that metabolites suffer various kin
 ds of damage\, that such damage happens in all organisms\, and that cells 
 have dedicated systems for damage repair and containment. Firstly\, chemic
 al biology is demonstrating that diverse metabolites are damaged by side-r
 eactions of ‘promiscuous’ enzymes or by spontaneous chemical reactions
 \, that the products are useless or toxic\, and that the unchecked buildup
  of these products can be devastating. Secondly\, genetic and genomic evid
 ence from pro- and eukaryotes is implicating a network of novel\, conserve
 d enzymes that repair damaged metabolites or somehow pre-empt damage. Meta
 bolite (i.e. small molecule) repair is analogous to macromolecule (DNA and
  protein) repair and appears from comparative genomic evidence to be equal
 ly widespread. Comparative genomics also implies that metabolite repair co
 uld be the function of many conserved protein families lacking known activ
 ities. How – and how well – cells deal with metabolite damage impacts 
 fields ranging from medical genetics to metabolic engineering and syntheti
 c biology.\n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\nLinst
 er\, C.L.\, Van Schaftingen\, E.\, and Hanson\, A.D. (2013). Metabolite da
 mage and its repair or pre-emption. Nat. Chem. Biol. 9: 72–80.\n\nVan Sc
 haftingen\, E.\, Rzem\, R.\, Marbaix\, A.\, Collard\, F.\, Veiga-da-Cunha\
 , M.\, and Linster\, C.L. (2013). Metabolite proofreading\, a neglected as
 pect of intermediary metabolism. J. Inherit. Metab. Dis. 36: 427–434.\n\
 nDanchin\, A.\, and Sekowska\, A. (2014) The logic of metabolism and its f
 uzzy consequences. Environ. Microbiol. 16: 19–28.\nGladyshev\, V.N. (201
 2). On the cause of aging and control of lifespan: heterogeneity leads to 
 inevitable damage accumulation\, causing aging\; control of damage composi
 tion and rate of accumulation define lifespan. Bioessays 34: 925–929.
LOCATION:Department of Biochemistry\, Hopkins Building\, Seminar Room 1
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