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SUMMARY:CANCELLED -                                                       
     &quot\;Synergistic effect of radiotherapy and cis-platinum chemotherap
 y delivered via gold nanoparticles in glioblastoma multiforme&quot\; - Dr 
 Sara Piccirillo\, Department of Clinical Neurosciences and Alexandra Vaide
 anu\, Deptatment of Engineering 
DTSTART:20150908T110000Z
DTEND:20150908T120000Z
UID:TALK60693@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:Alexandra G. Vaideanua\, Sonali Setuaa\, Myriam Ouberaia\, Col
 in Wattsb\, Mark Wellanda\, \naNanoscience Centre\, Department of Engineer
 ing\, University of Cambridge\, bJohn van Geest Centre for Brain Repair\, 
 Department of Clinical Neurosciences\, University of Cambridge\, Forvie Si
 te\, Robinson Way\, Cambridge \n\nGlioblastoma multiforme is one of the mo
 st aggressive types of cancer.  Despite current therapies and standard car
 e patients survive on average 14 months after diagnosis. The aim of our wo
 rk is to demonstrate the efficacy of a multimodal nanotechnology based on 
 gold nanoparticles in killing glioblastoma cells in human tissue derived c
 ell lines in vitro. We have showed previously1 the synergistic effect of c
 hemotherapy and radiotherapy in a construct based on spherical gold nanopa
 rticles coated with mercaptoundecanoic acid (MUA) to which we attached cis
 -platinum drug. The increased radiosensitization due to the gold atoms and
  the delivery of cis-platinum to the tumour cells resulted in a decreasing
  trend in the recurrence and survival of the cell lines tested. To further
  improve the technology we have used a modified construct in which we repl
 ace the MUA coating with a polyethyleneglycol (PEG) linker. This improved 
 the uptake of nanoparticles via an enhanced permeability retention effect 
 facilitated by the leaky tumour vasculature and as a consequence of reduce
 d interaction of PEG shielded carriers with opsonins. Further strategies i
 n maximizing the efficiency of the system include the attachment of a tumo
 ur homing peptide\, GRGDR\, to specifically target receptors at the surfac
 e of glioblastoma cells. The end goal of this work is to validate these fi
 ndings via in vivo mouse models and to ultimately submit this technology f
 or clinical trials. \n\n1. Setua\, S.\, Ouberai\, M.\, Piccirillo\, S. G.\
 , Watts\, C. & Welland\, M. Cisplatin-tethered gold nanospheres for multim
 odal chemo-radiotherapy of glioblastoma. Nanoscale 6\, 10865–10873 (2014
 )
LOCATION:CRUK CI Lecture Theatre
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