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SUMMARY:Multifunctional Magnetic Nanoparticles for Drug Delivery and Cell 
 Tracking - Professor Gang Bao (Department of Bioengineering\, Rice Univers
 ity)
DTSTART:20151014T150000Z
DTEND:20151014T160000Z
UID:TALK60782@talks.cam.ac.uk
CONTACT:Ms Helen Gardner
DESCRIPTION:A major goal of nanomedicine is to have better controls over b
 iological processes for precision treatment of diseases\, including cancer
 . In this talk I will present the development of multifunctional magnetic 
 nanoparticles for guided delivery of therapeutic agents and cells\, and fo
 r combined chemo- and hyperthermia-therapy. Specifically\, we performed a 
 systematic study on using magnetic force to alter biological processes suc
 h as endocytosis\, cell migration and tissue permeability. Our results ind
 icate that magnetic nanoparticles internalize info cells through an energy
 -dependent endocytic pathway\, and the rate of endocytosis can be controll
 ed by nanoparticle size and the applied magnetic force. The intracellular 
 magnetic force can induce rearrangements of stress fibers\, which leads to
  a reversible disruption of the tight junctions among endothelial cells. W
 e also demonstrated that magnetic nanoparticles have the potential for use
  as a multimodal cancer therapy agent due to their ability to carry antica
 ncer drugs and generate localized heat when exposed to an alternating magn
 etic field\, resulting in combined chemotherapy and hyperthermia. Taken to
 gether\, our studies suggest that the use of magnetic nanoparticles provid
 es a means for magnetically controlled delivery of drug molecules and cell
 s\, and opens up new opportunities for nanotherapeutics.
LOCATION:Language Unit Meeting Room
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