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SUMMARY:Novel imaging of cancer: Exciting and detecting new contrast - Sar
 ah Bohndiek (University of Cambridge)
DTSTART:20151001T180000Z
DTEND:20151001T193000Z
UID:TALK60791@talks.cam.ac.uk
CONTACT:Dr. Andrew Clarke
DESCRIPTION:Oxidative stress and metabolic alterations in cancer are assoc
 iated with malignant transformation\, disease aggressiveness and the evolu
 tion of drug resistance. However\, the interplay between oxidative stress\
 , blood oxygenation and hypoxia in cancer has yet to be fully understood. 
 Despite the clear role of oxidative stress in disease\, there are few clin
 ical methods to image the spatial distribution of oxygen or redox state in
  patients.\n Profound discoveries in physics lie at the heart of medical i
 maging\; techniques such as MRI and PET have revolutionised diagnostic med
 icine in the last 30 years. Our research program aims to develop and trans
 late new technologies that exploit visible and near-infrared light for ima
 ging of oxygen and oxidative stress in cancer. This either requires us to 
 go directly to the site of interest through endoscopy or to enhance the de
 pth of penetration of our approach using hybrid techniques such as optoaco
 ustic imaging. Instrument development and technical validation are perform
 ed in our Physics laboratories\, while biological validation is undertaken
  in our preclinical multimodality imaging facility using cancer models in 
 living subjects and comparing to existing gold standards. Using these new 
 imaging techniques\, we aim to better understand the interplay between oxi
 dative stress and hypoxia in cancer.\n
LOCATION:Schlumberger Cambridge Research
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