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SUMMARY:From mesoderm mechanotransductive evolutionary origins  to tumouro
 genic mechanical induction - Emmanuel Farge\, Institute Curie\, Paris
DTSTART:20151203T160000Z
DTEND:20151203T170000Z
UID:TALK60940@talks.cam.ac.uk
CONTACT:Sarah Harrison
DESCRIPTION:Bilaterians are complex organisms\, characterized by the exist
 ence of a mesoderm tissue from which most of animal complex organs develop
 . Mesoderm emerged 570 millions years ago from cnidarians that are charact
 erized by and ectoderm and an endoderm only. The lack of conservation of b
 iochemical signalling proteins upstream of early embryonic mesoderm differ
 entiation across bilaterians prevents to answer the question of the signal
  having been at the origin evolutionary origin of mesoderm emergence and c
 omplex animals. Here we found the mechano-transductive phosphorylation of 
 the Y654 site of beta-catenin by the first morphogenetic movements of embr
 yogenesis\, leading to its release into the cytoplasm and nucleus\, as inv
 olved and conserved in earliest mesoderm differentiation in the vertebrate
  zebrafish and un-vertebrate Drosophila\, two species having directly dive
 rged from the last common ancestor of bilaterians. We proposed mechanical 
 activation of beta-catenin signalling as having initiated the evolutionary
  transition to mesoderm differentiation and complex animals evolutionary e
 mergence1.We additionally find mechanical activation of beta-catenin as in
 volved in the mechanical activation of tumorogenic biochemical pathways\, 
 in the healthy epithelium compressed by the neighbouring tumour\, in respo
 nse to tumour growth pressure in vivo 2-4.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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