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SUMMARY:Sampling of RNA folding pathways - Tristan Cragnolini
DTSTART:20151009T110000Z
DTEND:20151009T114000Z
UID:TALK61399@talks.cam.ac.uk
CONTACT:Alex Thom
DESCRIPTION:Sampling of RNA folding pathways\n\nRNA molecules play many cr
 ucial biological roles\, and need to fold into specific conformations to f
 unction properly. The folding process takes place over long time scales\, 
 up to several hours. RNA molecules also often exhibit metastability\, with
  transitions between alternate folded conformations.\nTo investigate these
  processes using a detailed description of those molecules\, efficient sam
 pling methods are required.\n\nI will present several methods that allow t
 o sample the conformational space of those systems\,\nand highlight their 
 respective strengths when applied to study the energy landscapes of RNA mo
 lecules\nrepresented with HiRE-RNA\, a coarse-grained model of RNA\, and h
 ow they provide informations relatable to experimental data.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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