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SUMMARY:Designing Nanoparticles as Medical Tools - Dr Gemma-Louise Davies
DTSTART:20151111T210000Z
DTEND:20151111T220000Z
UID:TALK61586@talks.cam.ac.uk
CONTACT:Jamie Fox
DESCRIPTION:Nanosized materials have the potential to revolutionise a vari
 ety of different fields\, due to unique properties associated with their s
 mall sizes. In this talk\, I will describe efforts to design nanomaterials
  as medical imaging tools as well as for high efficacy therapeutics. Nanop
 article-based magnetic resonance imaging (MRI) agents provide superior con
 trast enhancements compared to their molecular (clinically used) Gd(III) a
 nalogues\; tuning the sub-particle localisation of Gd(III) macrocycles wit
 hin a mesoporous scaffold has a dramatic effect on their contrast capabili
 ty – providing contrast agents with unprecedented relaxivity. Iron oxide
  based nanocomposites can be carefully engineered to provide strong contra
 st signal\, significantly better than current commercial species\, at low 
 and clinically-relevant fields. Finally\, engineering the surface chemistr
 y of mesoporous silica nanoparticles allows control over their subcellular
  distribution. Conjugation of a specific cytochrome to such cytosol-access
 ing particles can induce programmed cell death across a population of canc
 er cells with remarkable efficiency.\n\nDr. Davies is a senior research fe
 llow in the Department of Chemistry at the University of Warwick\, where s
 he specialises in nanomaterial research. This highly interdisciplinary fie
 ld involves inorganic particle preparation and organic synthesis overlappi
 ng with the life sciences.
LOCATION:Nihon Room\, Pembroke College
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