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SUMMARY:Evolution\, classification and dynamics of protein complexes - Sar
 ah Teichmann
DTSTART:20151015T110000Z
DTEND:20151015T120000Z
UID:TALK61632@talks.cam.ac.uk
CONTACT:Salvatore Tesoro
DESCRIPTION:Classification of protein structure has had a broad impact on 
 our understanding of biological function and evolution\, yet this work has
  largely focused on individual protein domains and their pairwise interact
 ions. In contrast\, the assembly of individual polypeptides into protein c
 omplexes\, which are ubiquitous in cells\, has received comparatively litt
 le attention. The periodic table of protein complexes is a new framework f
 or analysis of complexes based on the principles of self-assembly. This re
 veals that sequence-identical subunits almost always have identical assemb
 ly roles within a complex and allows us to unify the vast majority of comp
 lexes of known structure (~32\,000) into about 120 topologies. This facili
 tates the exhaustive enumeration of unobserved protein complex topologies 
 and has significant practical applications for quaternary structure predic
 tion\, modelling and engineering
LOCATION:TCM Seminar room\, 530 Mott building
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