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SUMMARY:Looking at proteins in live cells with atomic resolution: From Sci
 ence Fiction to Science Reality - Dr. Phil Selenko\, FMP Berlin
DTSTART:20151014T093000Z
DTEND:20151014T103000Z
UID:TALK61652@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Dr. Phil Selenko\, will provide an update on his developments 
 that enable in-cell aggregate characterisation. Hee will present recent pr
 ogress in applying in-cell NMR and EPR methods to delineate full-scale ato
 mic-resolution descriptions of the structure(s) and dynamics of the intrin
 sically disordered human amyloid protein alpha-synuclein in different mamm
 alian cell types. Specifically\, he will address whether specialized cells
  such as dopaminergic neurons promote the conversion of monomeric alpha-sy
 nuclein into folded helical tetramers as has been suggested recently. In t
 hat sense\, 'to fold or not to fold' is the question that he intends to an
 swer in this seminar.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theater
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