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SUMMARY:&quot\;Blood-based biomarkers of Alzheimer's disease &amp\; Tempor
 al Clustering of biological\, medical and wearable data&quot\; - Dr Steven
  Kiddle MRC SGDP Centre\, Institute of Psychiatry\, King's College London
DTSTART:20151208T143000Z
DTEND:20151208T153000Z
UID:TALK61690@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:Our research focuses on looking for heterogeneity in disease t
 ype and disease stage. Understanding and detecting this heterogeneity will
  be important for developing stratified medicine approaches.\n\nI will sta
 rt by giving a brief overview of the research that we have done to look fo
 r blood-based biomarkers (genetic\, proteomic and metabolomics) of Alzheim
 er¹s disease\, for the enrichment of prevention trials.\n\nThe majority o
 f the talk will be dedicated to early work on the detection of heterogenei
 ty in the progression of continuous measures. This work can be seen as an 
 attempt to use time series data to better phenotype individuals. To achiev
 e this we have been using and developing clustering approaches that are se
 nsitive to time-delayed correlation\, but that can cope with heterogeneous
  sparse time points. I will present a simulation study before showing exam
 ples using biological\, medical and wearable (i.e. remote monitoring techn
 ology) datasets.
LOCATION:Large  Seminar Room\, 1st Floor\, Institute of Public Health\, Un
 iversity Forvie Site\, Robinson Way\, Cambridge
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