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SUMMARY:Defining Transcription factor specificity and redundancy in Drosop
 hila - Professor Steve Russell\, Department of Genetics.
DTSTART:20151118T140000Z
DTEND:20151118T150000Z
UID:TALK61929@talks.cam.ac.uk
CONTACT:38916
DESCRIPTION:In general\, metazoan transcription factors (TFs) are found in
  families of closely related genes that have most likely arisen through du
 plication and divergence during evolution. Often the proteins encoded by d
 uplicated genes have similar structures and recognise similar\, if not ide
 ntical\, binding sites\, raising questions as to how individuals TFs are a
 ble to direct specific regulatory outputs. In some cases this is achieved 
 by divergent expression\, with different proteins expressed in different c
 ell types or at different developmental stages. However\, in other cases\,
  closely related TFs are expressed in the same cells at the same time and 
 show considerable genetic redundancy\, raising the question of how evoluti
 on maintains redundant functions.  We have been examining the function\, s
 pecificity and redundancy associated with two classes of transcription fac
 tors in Drosophila - Hox and Sox - This seminar will overview the experime
 ntal approaches we take to studying these proteins\, what we have learned 
 and some of the many questions still remaining.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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