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SUMMARY:Adventures in structural variation and evolution in cancer - Tony 
 Papenfuss (WEHI + Peter Mac Melbourne)
DTSTART:20151116T153000Z
DTEND:20151116T163000Z
UID:TALK62069@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Cancer is a disease of evolution gone wrong. A major focus of 
 my lab's work is understanding cancer evolution and developing methods to 
 make sense of this data. In this talk\, I will discuss two recent projects
  aimed at understanding the evolution of two different cancers.\n\nIn the 
 first part of the talk\, I will discuss published work on cancer-associate
 d neochromosomes. These are massive chromosomes that harbor oncogenic driv
 ers. They are rare overall\, but common in certain rare cancers. We sequen
 ced neochromosomes isolated by flow sorting. This data allowed us to map t
 he contents and structure of neochromosomes at high resolution and develop
  a new model for their formation. In the second part of the talk\, I will 
 discuss work in progress on understanding the evolution of advanced metast
 atic melanoma from a rapid autopsy program at the Peter MacCallum cancer c
 entre and describe some of the hypotheses we're developing from this data.
  Along the way\, I'll describe some of the tools we've developed to help m
 ake sense of the data\, especially in the prediction of structural variant
 s.\n
LOCATION:CRUK CI Lecture Theatre
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