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SUMMARY:Computational Neuroscience Journal Club - David Zoltowski (Univers
 ity of Cambridge)
DTSTART:20151110T160000Z
DTEND:20151110T170000Z
UID:TALK62256@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:David Zoltowski will cover:\n\n* Single-trial spike trains in 
 parietal cortex reveal discrete steps during decision-making\n* K W Latime
 r\, J L Yates\, M L R Meister\, A. C. Huk and J. W. Pillow \n* http://www.
 sciencemag.org/content/349/6244/184.abstract\n\nNeurons in the macaque lat
 eral intraparietal (LIP) area exhibit firing rates that appear to ramp upw
 ard or downward during decision-making. These ramps are commonly assumed t
 o reflect the gradual accumulation of evidence toward a decision threshold
 . However\, the ramping in trial-averaged responses could instead arise fr
 om instantaneous jumps at different times on different trials. We examined
  single-trial responses in LIP using statistical methods for fitting and c
 omparing latent dynamical spike-train models. We compared models with late
 nt spike rates governed by either continuous diffusion-to-bound dynamics o
 r discrete “stepping” dynamics. Roughly three-quarters of the choice-s
 elective neurons we recorded were better described by the stepping model. 
 Moreover\, the inferred steps carried more information about the animal’
 s choice than spike counts.\n
LOCATION:Cambridge University Engineering Department\, CBL\, BE-438 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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