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SUMMARY:Pathways of protein quality control in the cytosol - Dr. Ramanujan
  Hegde\, LMB Cambridge
DTSTART:20151104T103000Z
DTEND:20151104T113000Z
UID:TALK62285@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Approximately 25% of all genes encode integral membrane protei
 ns that must be selectively targeted to and inserted into various intracel
 lular membranes. These hydrophobic membrane proteins must necessarily tran
 sit the cytosol en route to their final destination. Our group has been in
 vestigating how cytosolic factors shield these membrane proteins to preven
 t aggregation and how they are correctly targeted to their final destinati
 on. These destinations include the endoplasmic reticulum\, mitochondria\, 
 or the proteasome. Over the past several years\, we have begun to identify
  and analyze the factors involved in membrane protein traffic and degradat
 ion in the cytosol. These include the factors for tail-anchored membrane p
 rotein targeting to the ER and degradation factors for elimination of mis-
 targeted membrane proteins. We are now dissecting the inter-relationships 
 between these various factors to determine how membrane proteins are triag
 ed appropriately to maintain cytosolic protein homeostasis.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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