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SUMMARY:DNMT3A in Hematopoietic Stem Cells\, Cancer and Ageing - Margaret 
 A. Goodell\, Baylor College of Medicine\, Houston
DTSTART:20160218T130000Z
DTEND:20160218T140000Z
UID:TALK62352@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:DNA methyltransferase 3a (DNMT3A) has recently emerged as an i
 mportant tumor suppressor in hematologic malignancies\, and its ablation i
 n mouse hematopoietic stem cells inhibits differentiation. We will describ
 e the use of DNMT3A knockout mice to study its role in myeloid and lymphoi
 d malignancy development and its function in maintaining global DNA methyl
 ation.  The role of DNMT3A mutations in intercellular competition in the c
 ontext of ageing will also be discussed.
LOCATION:CRUK CI Lecture Theatre
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