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SUMMARY:Tumour suppressor and tumour maintenance genes - Scott Lowe\, Memo
 rial Sloan Kettering Cancer Centre\, New York
DTSTART:20160322T130000Z
DTEND:20160322T140000Z
UID:TALK62353@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Cancer arises through an evolutionary process whereby normal c
 ells acquire mutations that erode growth controls\, leading to the expansi
 on of aberrantly proliferating cells. Such mutations activate oncogenes or
  inactivate tumor suppressors\, each bestowing new\ncapabilities to emergi
 ng tumors. Still\, cancer is not an inevitable consequence of mutation but
  is instead kept in check by intrinsic tumor-suppressor programs activated
  in damaged cells. Accordingly\, our laboratory studies such mechanism in 
 order to reveal key regulatory nodes controlling basic cellular processes 
 and to identify the strategies nature uses to combat cancer. More recently
 \, our interests have expanded to explore the action of tumor maintenance 
 genes – those genes needed to sustain the proliferation and survival\nof
  malignant cancer cells – with the goal of dentifying cancer vulnerabili
 ties and therapeutic targets. Our approach combines powerful mouse models\
 , genetics\, and\ngenomics in a coordinated manner that allows us to study
  tumor suppressor and tumor maintenance networks in a comprehensive way. R
 ecent efforts to characterize tumor suppressor gene action and the consequ
 ences of tumor suppressor gene loss will be discussed.
LOCATION:CRUK CI Lecture Theatre
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