BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Understanding and targeting the ovarian cancer microenvironment - 
 Fran Balkwill\, Queen Mary University of London
DTSTART:20160414T120000Z
DTEND:20160414T130000Z
UID:TALK62354@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:The aim of our current work is to deconstruct the tumour micro
 environment of ovarian cancer metastases in order to inform in vitro and i
 n silico modelling of this disease and to aid testing of new biological th
 erapies. Specifically\, we are conducting high resolution profiling of the
  evolving tumour microenvironment of omental metastases of human high-grad
 e serous ovarian cancer\, HGSC. We have analysed higher order structures o
 f omental metastases\, architecture\, cellularity and biomechanical proper
 ties\, and related these to transcriptomic and proteomic data on the same 
 sample using multivariate analysis. This has allowed us to identify gene a
 nd protein expression patterns that best predict the higher order structur
 es. Our results suggest that investigation of multiple aspects of the evol
 ving tumour may be useful in generating more representative models of its 
 microenvironment\, providing information that complements data obtained fr
 om studying a single parameter in larger numbers of biopsies.
LOCATION:CRUK CI Lecture Theatre
END:VEVENT
END:VCALENDAR