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SUMMARY:Using Mouse Models to Understand Metastatic Spread and Tumour Hete
 rogeneity - Ben Stanger\, Perelman School of Medicine\, University of Penn
 sylvania
DTSTART:20160630T120000Z
DTEND:20160630T130000Z
UID:TALK62357@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Each cancer is different\, harboring unique genetic and epigen
 etic differences which make it distinct from every other tumour\, and even
  within a given tumour\, sub-clones with distinct properties evolve during
  tumour progression. This inter- and intra-tumoural heterogeneity creates 
 a challenge for understanding tumour biology\, since each tumour is a comm
 unity of cells (containing both cancer and non-cancer cells) rather than a
  single entity. For several years\, we have used mouse models to understan
 d the cellular and molecular events underlying pancreatic cancer\, a highl
 y lethal malignancy that is prone to metastasis and resistant to most stan
 dard therapies. In particular\, we have applied the technique of lineage t
 racing to understand metastatic progression and tumour-stroma interactions
 . In the talk\, we will describe ongoing efforts using the model to unders
 tand both intra- and inter-tumoural heterogeneity in the context of a spon
 taneously evolving tumour.
LOCATION:CRUK CI Lecture Theatre
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