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SUMMARY:Bottlenecks\, diversity and phase variation during infection\; the
  pneumococcal model. - Professor Marco Oggioni\, Department of Genetics\, 
 University of Leicester
DTSTART:20160113T160000Z
DTEND:20160113T170000Z
UID:TALK62616@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Bottlenecks and selective pressures generated by the host shap
 e bacterial populations which in turn react by increasing diversity genera
 ting mechanisms including phase variation. Using Streptococcus pneumoniae\
 , a mayor human pathogen\, as model we have defined bottlenecks down to a 
 single cell at the beginning of sepsis and identified bacterial genes unde
 r very strong selection. Such events reduce diversity and potentially popu
 lation fitness drastically. On the other hand we found high mutation frequ
 encies in the host and evidence for a phase variable methylation system wh
 ich significantly impact on bacterial physiology to regain diversity possi
 bly in order to adapt to changing environments. The seminar will try to gi
 ve an overview on our ongoing research and also address if these investiga
 tions are a mere academic exercise or if they could have any potential imp
 act.\n-Gerlini PLoS Pathogens 2014\n-Manso Nature Communications  2014\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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